- Title
- Small molecule inhibitors of protein kinases in cancer: how to overcome resistance
- Creator
- Griffith, R.; Brown, M. N.; McCluskey, A.; Ashman, L. K.
- Relation
- Mini-Reviews in Medicinal Chemistry Vol. 6, Issue 10, p. 1101-1110
- Relation
- http://www.bentham.org/mrmc/contabs/mrmc6-10.htm#5
- Publisher
- Bentham Science Publishers Ltd.
- Resource Type
- journal article
- Date
- 2006
- Description
- Small molecule protein kinase inhibitors show great promise as anti-cancer agents, however, de novo and acquired resistance present problems. These are reviewed and illustrated using the receptor tyrosine kinase, KIT, as an example. Emerging solutions are presented, such as targeting active kinase conformations.
- Subject
- small molecule protein kinase inhibitors; anti-cancer agents; de novo; receptor tyrosine kinase; KIT; active kinase conformations
- Identifier
- http://hdl.handle.net/1959.13/31726
- Identifier
- uon:2784
- Identifier
- ISSN:1389-5575
- Language
- eng
- Reviewed
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